";s:4:"text";s:20325:"Sep 2017 - Aug 20181 year. 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. Gamble, C., Davies, W., Pettitt, P., Hazelwood, L. & Richards, M. The archaeological and genetic foundations of the European population during the Late Glacial: implications for agricultural thinking. Key, F. M. et al. Weissensteiner, H. et al. Inconsistent haplogroup assignments were manually verified as indicated24 (Supplementary Data 1.L). The genomic history of southeastern Europe. Brunel, S. et al. 1 MtDNA and Y-chromosome phylogenies. Natural Language Processing (NLP) is another technique that has a well-deserved position in product development. Its not just the top 200 that this competition attracts, but anyone interested in data science. Even better your perks will stay yours even after you complete the course. Low latency, reasonably low communication overhead and ability to support real time applications are the reasons for . This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). Publications. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Tina Huang - Instructor | 365 Data Science 9, 442 (2018). Tina Huang is very empowering, and she knows what she is talking about. Kircher, M., Sawyer, S. & Meyer, M. Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. volume615,pages 117126 (2023)Cite this article. Tina Huangis a data scientist currently working at a large FAANG enterprise. Its also hard to predict whats going to happen, but I hope its interesting to people who want to learn more about data science. Tina's authentic and engaging delivery style allows her to create original content on topics like how to be more productive, how to learn more efficiently, how to land a job in data science . 1925). Grizz, Panda i Lodomir maj rne charaktery, ale pomimo odmiennoci potrafi wspdziaa i wspiera si w kopotach. Skoglund, P. et al. We used the default posterior threshold of 0.01, and mapping and sequencing quality cutoffs of 30. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. Article The responsible co-authors for the material from each archaeological site are listed in Supplementary Information, section 1. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Ampliar bsqueda. This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Dr. Huang taught General Chemistry, Quantitative Analysis, and Instrumental Methods for eight years at . Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. get subscribed to the Brandwatch Bulletin. Science 358, 659662 (2017). The grouping of Epigravettian-associated populations is shown with the same colour in a. Jagwire Europe - Fevacom NV . 1 and 2). With the statistics f4(Mbuti, Fournol 85; Vstonice, test) and f4(Mbuti, Vstonice; Fournol 85, test), we show that all Vstonice-cluster individuals are significantly closer (|Z|>3) to the Vstonice group (n=5) and the Fournol-cluster individuals are closer to Fournol 85, whereas the geographically intermediate Gravettian-associated Goyet group shows extra affinity to both clusters (Fig. This means that you have to set up the database tables to represent the data (which can be done by using the right database design patterns) and then run some SQL queries to extract the data that you need. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. a, Geographic locations of newly reported individuals (filled symbols with black outline) and representative previously published individuals (outlined stars). Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. After another MinElute purification, the product was quantified using the Agilent 2100 Bioanalyzer DNA 1000 chip. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. Details are provided in Data S2.B. Tina Huang - Data Scientist - Children's Hospital Los Angeles (CHLA 29, 11691177.e7 (2019). In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. 3,528. is also supported by the Deutsche Forschungsgemeinschaft (DFG FOR 2237). Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. To gain an overview of the genomic background of European hunter-gatherers before the LGM, we used multidimensional scaling (MDS) to plot a dissimilarity matrix of pairwise outgroup f3-statistics in the form 1f3(Mbuti; pop1, pop2) (Fig. The pre-40kagroup and theFournol and Vstonice clusters are marked as shaded areas in different colours. About the Instructor. CAS W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym . J. Archaeol. Zool. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. YourCourse Certificatehas no expiration date. Note added in proof:A companion paper51describes genome-wide data of a 23,000-year-old Solutrean-associated individual from southern Iberia that extend the evidence of genetic continuity across the LGM in southwestern Europe. The labels in italic denote previously published individuals without new data generated in this study. What is surprising is that the Code Cup was so popular that Stanford decided to throw open a Data Science Week in which anyone can submit a code challenge to the top 200 submissions. Sign In Create Free Account. DNA analysis of an early modern human from Tianyuan Cave, China. Powered by Symplectic part of Digital Science . Double-stranded DNA libraries were built from 25l of DNA extract, without the presence of uracil DNA glycosylase (ds_nonUDG) or in the presence of uracil DNA glycosylase (ds_halfUDG), following a double-stranded UDG-half library preparation to reduce, but not eliminate, the amount of deamination-induced damage towards the ends of ancient DNA (aDNA) fragments58. 4, 11 (2007). To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. TV Actress. The ROH segments in hunter-gatherer genomes were identified using hapROH101. Tina Huang - Test and Validation Engineer - LinkedIn Save my name, email, and website in this browser for the next time I comment. Christina Yu-Ting Wang - Design Team Lead - TomTom | LinkedIn Saag, L. et al. Great explanations and feels like real interviews that helps me warm up myself before the real interview! YSYS stands for Your Startup, Your Story and is dedicated to connecting diverse people with opportunities in tech.. "Further interdisciplinary research will clarify which exact processes were responsible for the genetic replacements of entire Ice Age populations.". As of right now, it doesnt seem that MySQL is the right choice for storing data because the database is so large, it would be impossible to find and query the necessary information. Most data scientists are used to having to do the dirty work of cleaning and cleansing data. However, using f4-statistics, we show that all Magdalenian-associated individuals, and not only El Mirn, carry Villabruna-related ancestry whencompared tothe Fournol cluster(Supplementary Data 2.H). Here, data really gets to shine, in that its both the source of truth and the driver of insights. Rivollat, M. et al. Nature 592, 253257 (2021). In addition, those groups also carry affinity to ANF suggesting more complex genetic processes behind their demographic history16. ADS Long-term Outcomes in Critically Ill Patients With COVID-19 in the Correspondence to Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. Most Popular #86731. The two 14ka Oberkassel individuals mark the earliest presence of WHG ancestry north of the Alps, which we therefore rename the Oberkassel cluster(hereafter, Oberkassel cluster or ancestry), using the name of the oldest reported individual to date carrying such ancestry with more than one-fold coverage, for consistency4. The previous inhabitants may have migrated to the north as their habitat, the 'mammoth' steppe, dwindled," says Johannes Krause, the study's senior author. You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. Open access funding provided by Max Planck Society. Curr. The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). Nat. HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. The error bar shows the s.e.m. Thank you for visiting nature.com. Genome Biol. USA 110, 22232227 (2013). ADS 9; the entire IT and laboratory teams at the Department of Archaeogenetics of MPI-SHH for technical assistance; M. Meyer and S. Nagel for support with single-stranded library preparation; K. Post, P. van Es, J. Glimmerveen, M. Medendorp, M. Sier, S. Dikstra, M. Dikstra, R. van Eerden, D. Duineveld and A. Hoekman for providing access to human specimens from the North Sea (The Netherlands); M. D. Garralda and A. Estalrrich for providing access to human specimens from La Riera (Spain); J. Grski andM. Zajcfor providingaccess tohuman specimensfromMaszycka cave;C. Di Patti for providing access to human specimens from San Teodoro 2 (Italy); P. Blaeviius for providing access to the Donkalnis human remains and the new radiocarbon dates; the Italian Ministry of Culture and Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Verona, Rovigo, and Vicenza for granting access to the human remains of Tagliente 2; F. Fontana, who carries out investigations of the Riparo Tagliente site (Italy); the Friuli Venezia Giulia Superintendency for providing access to the human tooth Pradis 1; and the Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Barletta-Andria-Trani and Foggia for providing access to the Paglicci human remains. Tina Huang: Xiamen Guansheng Precision Machinery Co Ltd is a eLife 11, e77625 (2022). This research aims to determine whether a neural response telemetry (NRT) threshold determines the success of surgery. Former Apple and Twitter Engineer Explains Why She Started - Insider H. Rougier and I.C. What is Connection Map in Data Visualization? Protoc. Green, R. E. et al. Nat. The oldest individual in the Fournol cluster is Ormesson 2988 from northeastern France (31ka, Early/Middle Gravettian), whereasa Gravettian group from Goyet in Belgium (27ka, Late Gravettian) is found to be a mixture between the Vstonice and Fournol clusters. Culturally, however, we see both widespread general tendencies, such as weaponry and some portable art48, and other aspects that have a more regional character, such as mortuary practices (Supplementary Information, section13), various originalities in lithic and hard organic materials tool kits and adornments20,21. My name is Tina and I'm a data scientist and YouTuber. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. ), no. Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). Lifetime access to all course materials and updates. The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Ancient genomes from present-day France unveil 7,000 years of its demographic history. Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. SQL for Data Science Interviews . Mol. I love learning new things a. Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic. Check out Why is Burnout So Common in Tech? This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). What is a Pie Chart in Data Visualization? Tina Zhang - Brand Specialist - Dymind Biotechnology | ZoomInfo Shes the author of the popular Data Science: The Complete Guide and the creator of the popular Data Science Cookbook. She was also one of the founders of the Stanford Data Science Society. Living up to Expectations: The Strengths and Challenges Experienced by The first horse herders and the impact of early Bronze Age steppe expansions into Asia. Tina Huang. Hi! Tina Huang Profile page. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. Sci. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. Reimer, P. J. et al. ";s:7:"keyword";s:25:"tina huang data scientist";s:5:"links";s:1020:"When A Fearful Avoidant Pulls Away,
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