10.1212/WNL.0b013e3181e396ea. Cases have been reported in patients between 14 and 77 years of age 5. The link you have selected will take you to a third-party website. Article J Magn Reson Imaging. Harnsberger HR, Glastonbury CM, Michel MA et-al. I: Nair A, Sabbagh M, red. MRI of the Brain II. Superficial siderosisis a rare condition which results from the deposition of hemosiderin along the leptomeninges, with eventual neurological dysfunction. Disclaimer. Before eCollection 2022. Fearnley J, Stevens J, Rudge P. Superficial Siderosis of the Central Nervous System. Brain Nerve. PubMed statement and Although data are very limited, it is conceivable that lobar MBs could predict progression to AD-type dementia but that deep MBs could anticipate the future development of vascular dementia. (A) Multiple lobar microbleeds distributed across the temporal lobes. Hemosiderin deposition in the brain as the footprint of high-altitude cerebral edema. In some cases, it may develop in other areas of the body, such as the inside of the elbow, after intravenous iron injections. Second, direct extrapolations from the Boston Criteria for the diagnosis of CAA-related hemorrhage [22] (Table1) seem inadequate, as they have been validated only in subjects with lobar ICH. 10.1161/STROKEAHA.111.647271. Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA: Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Neuropathology of Vascular Brain Health: Insights From Ex Vivo Magnetic Resonance Imaging-Histopathology Studies in Cerebral Small Vessel Disease. Article Linn J, Halpin A, Demaerel P et al. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. 2022 Sep 2;23(17):10018. doi: 10.3390/ijms231710018. Werring DJ, Sperling R: Inflammatory cerebral amyloid angiopathyand amyloid-modifying therapies: variations on the same ARIA?. Stroke. AJNR Am J Neuroradiol. Conclusions: Stroke. 2022 Oct 19;65(4):270-277. doi: 10.33160/yam.2022.11.001. Check for errors and try again. Google Scholar. Over time, methemoglobin breakdown products are accumulated within the macrophages as hemosiderin and ferritin. Roher AE, Kuo YM, Esh C, Knebel C, Weiss N, Kalback W, Luehrs DC, Childress JL, Beach TG, Weller RO, Kokjohn TA: Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimers disease. The source of hemorrhage is not apparent in approximately 50% of patients despite extensive examination. Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P: Prevalence and severity of microbleeds in a memory clinic setting. Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, Krestin GP, Breteler MM, Vernooij MW: Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Aetiologically a haemorrhage (acute or chronic) is present in the subarachnoid space. Despite this high variability, MB overall prevalence is consistently higher in subjects with AD than in non-demented, older individuals [15, 50]. ARIA-H can occur spontaneously in patients with Alzheimer's disease. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MM: Cerebral microbleeds: a guide to detection and interpretation. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. Webb AJ, Flossmann E, Armstrong RJ. His symptoms worsened with time and he developed lower limb weakness and shortness of breath. MRI is the modality of choice for assessment and diagnosis of superficial siderosis. Overall, there is a male predilection (M:F 3:1) 2,5. The most common causes of hemorrhage in the "localized" type are cerebral amyloid angiopathy and/or Alzheimer's disease. This deposition of this "foreign" material can occur all along the CNS, including the brain and the spine. These results were stronger in subjects with strictly deep MBs. Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study. 10.1212/01.wnl.0000436609.20587.65. When specific causes of death according to MB distribution were investigated in a population-based cohort of older people at high risk of cardiovascular disease, deep MBs were associated with cardiovascular mortality, whereas lobar MBs were associated with stroke-related mortality [40]. In fact, experimental studies have shown that MBs may transiently affect the function of the nearby cells because of an inhibition of stimulus-evoked calcium responses [31]. Tanaka A, Ueno Y, Nakayama Y, Takano K, Takebayashi S: Small chronic hemorrhages and ischemic lesions in association with spontaneous intracerebral hematomas. The medical history was potentially consistent with Creutzfeldt-Jakob disease, but the 143-3protein in cerebrospinal fluid, which is used as a biomarker for the condition, was normal. It was also seen that the combination of multiple MBs and retinopathy increased the odds ratio of vascular dementia: 3.10; 95% confidence interval (CI) 1.11 to 8.62 [46]. Careers. Hemosiderin staining can also occur after . Arch Neurol. Although deep MBs may be identified in some AD cases, the vast majority of them (92%) show a lobar predominance. 10. 10.1212/WNL.0b013e31826043a9. 10.1161/STROKEAHA.108.516286. In this study of 3,979 participants, multiple MBs (at least five) were associated with worse cognitive performances in all domains but memory. One of the initial studies assessing the cognitive impact of MBs compared the performance on multiple cognitive domains between patients with and without MBs from a neurovascular clinic [44]. 10.1002/ana.22099. In "classical"-type SS, hypointense MRI signals are observed in the brainstem and cerebellum with diffuse and symmetrical margins. Hemosiderosis can result from. Stroke. 2012, 31: 259-263. no financial relationships to ineligible companies to disclose. doi: 10.5114/pjr.2021.110650. 2013, 8: e65663-10.1371/journal.pone.0065663. Use OR to account for alternate terms 2005, 110: 345-359. In this case, low MB counts may have prevented this study from identifying associations. Would you like email updates of new search results? Superficial hemosiderosis is a neurodegenerative disorder resulting from recurrent leakage of blood into the subpial space. Become a Gold Supporter and see no third-party ads. AJNR Am J Neuroradiol. It also shows up in people who have inflammation in the layer of fat beneath the skin of the lower legs (lipodermatosclerosis). Patients tend to also exhibit other manifestations of hemochromatosis . Seo and colleagues [45] investigated the independent effect of MBs in multiple domains in a cohort of individuals with diagnosed subcortical vascular dementia. Hemosiderin deposition is the consequence of recurrent or persistent hemorrhage in the subarachnoid space. PLoS One. Unauthorized use of these marks is strictly prohibited. Haemosiderin deposition and vascular pathology in the putamen were quantified in 200 brains donated to the population-representative Medical Research Council Cognitive Function and Ageing Study. Greater putamen haemosiderin was significantly associated with putaminal indices of small vessel ischaemia (microinfarcts, P < 0.05; arteriolosclerosis, P < 0.05; perivascular attenuation, P < 0.001) and with lacunes in any brain region (P < 0.023) but not large vessel disease, or whole brain measures of neurodegenerative pathology. Symptoms of compression neuropathy can be present if the lesion is in the vicinity of peripheral nerves (e.g., carpal tunnel or Guyon's canal). Hemosiderin is a strong paramagnetic material, which allows its detection when a magnetic field is applied [1]. 1991, 30: 637-649. 10.1212/WNL.0b013e3182452928. Google Scholar. Cianchetti FA, Kim DH, Dimiduk S, Nishimura N, Schaffer CB: Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. This argued against setting a strict limit for the maximum diameter of MBs; however, the study reported a value of 5.7 mm as the best cutoff to distinguish between the two types of hemorrhages [10]. Schrag M, McAuley G, Pomakian J, Jiffry A, Tung S, Mueller C, Vinters HV, Haacke EM, Holshouser B, Kido D, Kirsch WM: Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. This study showed that AD subjects with multiple MBs had a more severe cognitive impairment (independently of disease duration) and degree of atrophy and WMH [56]. 2015;15 (5): 382-4. 1999, 20: 637-642. Microhaemorrhages in connection with a previous haemorrhage are typical of amyloid angiopathy. Indeed, a recent study using high-field MRI found an MB prevalence as high as 78% in patients with early AD [7]. Objective: Based on recent findings of microhemorrhages (MHs) in the corpus callosum (CC) in 3 individuals after nonfatal high-altitude cerebral edema (HACE), we hypothesized that hemosiderin depositions in the brain after high-altitude exposure are specific for HACE and remain detectable over many years. If people have a disorder that causes excessive breakdown of red blood cells within the blood vessels (for example, hemolytic anemia Aplastic Anemia Aplastic anemia is a disorder in which the cells of the bone marrow that develop into mature blood cells are damaged, leading to low numbers of red blood cells, white blood cells, and/or platelets read more ), iron released from the red blood cells can accumulate within the kidneys (renal hemosiderosis). Adv Exp Med Biol. Staekenborg SS, Koedam EL, Henneman WJ, Stokman P, Barkhof F, Scheltens P, van der Flier WM: Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy. Superficial hemosiderosis of the 'classical type' is a rare but potentially serious condition resulting from leptomeningeal hemosiderin accumulation on the surface of the cerebellum, around the cranial nerves and spinal cord. 10.1111/j.1749-6632.2002.tb04813.x. and transmitted securely. Higher levels of putamen haemosiderin correlated with more CMB (P < 0.003). PubMed In this article, we aim to review the current knowledge on the pathophysiology and clinical implications of MBs, with special emphasis on the links between lobar MBs, cerebral amyloid angiopathy, and Alzheimers disease. 2007, 47: 564-567. Kumar N, Cohen-Gadol AA, Wright RA, Miller GM, Piepgras DG, Ahlskog JE. Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes.The breakdown of heme gives rise to biliverdin and iron. Differences in baseline characteristics between these two population-based cohorts may explain why deep or lobar location of MBs appears to be more prominent. Owing to the paramagnetic properties of blood degradation products, MBs can be detected in vivo by using specific magnetic resonance imaging (MRI) sequences. 2004, 52: 612-618. 10.1161/STROKEAHA.108.531343. 2005, 20: 412-414. 2017 Apr 1;140(4):1107-1116. doi: 10.1093/brain/awx003. Methods: This was a cross-sectional study involving 37 mountaineers in 4 groups: 10 had . Acta Neurochir (Wien). 2008, 255: 1679-1686. Possible sources include brain or spine trauma, neurosurgery, cerebral or . However, these associations were more robust in individuals with strictly lobar MBs (all analyses adjusted for age, sex, education, vascular risk factors, other SVD markers, and brain atrophy). Molecular markers of gliosis and tissue integrity were assessed by immunohistochemistry in brains with highest (n = 20) and lowest (n = 20) levels of putamen haemosiderin. Superficial siderosis following spontaneous intracranial hypotension. However, at what time point mild symptoms will progress was entirely based on personal clinical and surgical experience. Epub 2017 Jun 5. Not all patients have an identifiable source of hemorrhage. AJNR Am J Neuroradiol. 10.1159/000139661. Neurology. Google Scholar. eCollection 2021. 10.1159/000092958. 2010;113 (1): 97-101. government site. 2012, 79: 763-769. Accessibility View Yuranga Weerakkody's current disclosures, see full revision history and disclosures, dural defect with spinal CSF collections/spinal cyst, fragile capillary regrowth after brain surgery, cerebellar bleeding following craniectomy, spinal surgery or lumbar puncture. 2011, 68: 656-659. 2016 Dec;139(Pt 12):3151-3162. doi: 10.1093/brain/aww229. Neurology. [PubMed][CrossRef]. Although CNS involvement in hemochromatosis may be asymptomatic and incidentally noted radiographically, patients may present with: movement disorders (e.g. Also, a high frequency of MBs in severe vascular conditions like ischemic and hemorrhagic stroke has been noticed [17]. Google Scholar. 10.1212/WNL.0b013e3181eee40f. 2006, 66: 1356-1360. Cerebral microbleeds (CMBs) are a crucial radiological marker of cerebral small vessel disease (CSVD) to illustrate the micropathology of perivascular hemosiderin deposition corresponding to past small foci of bleeding ().The prevalence of CMBs increases with age and exceeds 20% in community population over 60 years old (3, 4).More importantly, CMBs are also a common comorbidity . Arch Neurol. 10.1212/01.wnl.0000210535.20297.ae. 2007 Apr;64(4):491-6. doi: 10.1001/archneur.64.4.491. The trusted provider of medical information since 1899. Ann Neurol. doi: 10.1136/bcr-2019-230431. Inform patients that most people with swelling in areas of the brain do not experience symptoms, however, some people may experience symptoms such as headache, confusion, SM-R declares that he has no competing interests. CAA is caused by the accumulation of -amyloid on the vessel walls of cortical and leptomeningeal arteries. 9. Motta vrt nyhetsbrev! 10.1212/WNL.0b013e3182661f91. Hemosiderin deposition may be the first sign of a leaky avascular malformation, cyst or aneurysm. On a less direct level, diffusion tensor imaging studies have shown an independent association between the presence of MBs and a higher degree of microstructural injury of the brain [27, 28]. Neurology. In the literature, the risk/benefit ratio of anti-thrombotic drugs in individuals with MBs is controversial, and no formal contraindications in this respect exist. Ann Neurol. Cerebral microbleeds: overview and implications in cognitive impairment. 10.1212/WNL.43.10.2073. Clinically, hemosiderin hyperpigmentation is distinguished from postinflammatory dermal melanosis by a golden-brown hue, unlike the brown or gray-blue pigmentation of epidermal or dermal melanin, respectively. Superficial siderosis (SS) of the central nervous system (CNS) is a chronic condition consisting of hemosiderin deposition in the subpial layers of the brain (and spinal cord) due to chronic or intermittent low-grade extravasation of blood into the subarachnoid space. MeSH By using this website, you agree to our Stroke. National Library of Medicine Clipboard, Search History, and several other advanced features are temporarily unavailable. Stephan Johannes Schler (born 1967), specialist in neurology from Germany, from where he has his dr. For the cortical type, (transient) focal neurological symptoms are found, but also development of dementia (1). This site needs JavaScript to work properly. Because CAA is present in up to 90% of AD cases [52], it may be conceptually feasible to state that lobar MBs are reliable markers of CAA in patients with AD. official website and that any information you provide is encrypted Alz Res Therapy 6, 33 (2014). med., senior consultant. Pathology of the Vestibulocochlear Nerve. 1999, 30: 1637-1642. Over time, further sequences have been developed, including three-dimensional T2*-GRE [3] and the most sensitive one to date - susceptibility-weighted imaging (SWI) [4]. Brain. In this review, we aim to summarize the current knowledge on the pathophysiology and clinical implications of MBs, with special emphasis on the links between lobar MBs, cerebral amyloid angiopathy and Alzheimers disease. MBs have extraordinary importance in the context of AD. Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. 8600 Rockville Pike Google Scholar. The frequency of MRI CMB in 10 cases with highest and lowest burden of putamen haemosiderin, was compared using post mortem 3T MRI. eCollection 2022 Nov. Jordan N, Gvalda M, Cody R, Galante O, Haywood C, Yates P. Front Med (Lausanne). Symptoms can vary depending on the distribution of hemosiderin deposition. Akoudad S, de Groot M, Koudstaal PJ, van der Lugt A, Niessen WJ, Hofman A, Ikram MA, Vernooij MW: Cerebral microbleeds are related to loss of white matter structural integrity. Poels MM, Ikram MA, van der Lugt A, Hofman A, Krestin GP, Breteler MM, Vernooij MW: Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Given these observations, it seems reasonable to individualize decisions on anti-thrombotic therapy in patients with MBs. Stroke. Typical clinical findings for the classical type include hearing loss, ataxia, pyramidal tract signs (spasticity, paralysis) and headache. Cerebrovasc Dis. 10.1007/s00401-005-1074-9. Seo SW, Hwa Lee B, Kim EJ, Chin J, Sun Cho Y, Yoon U, Na DL: Clinical significance of microbleeds in subcortical vascular dementia. Further supporting this observation, PiB retention was shown to rapidly decrease with increasing distance from the MB site [24]. However, even given the lowest estimates, it appears that MBs are a common phenomenon across different patient populations. Typical symptoms include 2-5: It is important to realize that the degree of imaging abnormality does not always correlate with the degree of clinical impairment 4. Two early studies failed to demonstrate any influence of MBs on cognitive performance in AD cohorts [47, 49]. 10.1161/01.STR.30.8.1637. Results: CAS Stroke. (2010) ISBN: 9780781791861 -. Iron chelating agents have been tried with limited anecdotal success 6. Associations of mixed MBs resembled the profile of strictly deep MBs. Google Scholar. Hemochromatosis more often requires treatment. Stephan Johannes Schler, Kjell Arne Kvistad. 2019;1205:25-53. doi: 10.1007/978-3-030-31904-5_3. Neurology. 2009;8:165174. Consequently, the presence of advanced CAA has been established as a potential risk factor for developing undesirable brain inflammation in AD immunotherapy. 10.1002/ana.22112. 5. Bethesda, MD 20894, Web Policies Diagnostic Imaging: Head and Neck. Soo YO, Yang SR, Lam WW, Wong A, Fan YH, Leung HH, Chan AY, Leung C, Leung TW, Wong LK: Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. 2009, 30: 338-343. Hemosiderin is a stain, left behind after a brain bleed, even after though the blood is reabsorbed into the blood system. (B) Isolated deep microbleed in the lateral aspect of the right thalamus. At present, it is indirect evidence from population-based studies that mostly supports the associations between lobar/deep MBs and CAA/HV. Careers. 10.1159/000088665. In the United States, over 1 million people have read more . The downsides of these technical improvements are the increase in the blooming effect (larger visual appearance of MBs on MRI than the actual size of the hemosiderin deposit) [8] and the frequency of MB mimics, which raises concerns about potential overdetection of MBs and a limited clinical significance (especially if supporting pathological data are not available). Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome. An early trial of active immunization reported some cases of severe meningoencephalitis, which prompted its termination [60]. There still exists another line of investigation providing support to the link between lobar MB and CAA, and it consists of the study of CAA patients with both MRI and Pittsburgh compound B (PiB)-positron emission tomography (PET) imaging. Brant-Zawadzki (Editor), William G., Jr. Bradley (Editor), Jane Cambray-Forker (Editor). Philip J. Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street Suite 300, Boston, MA, 02114, USA, Sergi Martinez-Ramirez,Steven M Greenberg&Anand Viswanathan, You can also search for this author in 8600 Rockville Pike Neuroimaging-pathological correlation studies are needed to confirm these associations. Vernooij MW, Ikram MA, Wielopolski PA, Krestin GP, Breteler MM, van der Lugt A: Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection. Vestibulocochlear nerve (CN VIII) dysfunction resulting in a sensorineural hearing loss is believed to be due to the combination of a long cisternal course (thus with ample exposure to the subarachnoid space) and the susceptibility of microglial cells (which have a role in myelination) to be damaged by iron compounds 4. The amyloid cascade hypothesis [53], in combination with further theories on amyloid clearance through perivascular spaces [54], supports this notion. and transmitted securely. For instance, 7-Tesla MRI detects twice as many MBs in comparison to conventional 1.5-Tesla MRI [7]. MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden. Received 24.11.2016, first revision submitted 31.3.2017, accepted 9.5.2017. A few small histopathological studies have provided insight into the vascular anomalies associated with MBs [8, 1821]. 2008, 26: 142-146. Gurol ME, Dierksen G, Betensky R, Gidicsin C, Halpin A, Becker A, Carmasin J, Ayres A, Schwab K, Viswanathan A, Salat D, Rosand J, Johnson KA, Greenberg SM: Predicting sites of new hemorrhage with amyloid imaging in cerebral amyloid angiopathy. Kikuta K, Takagi Y, Nozaki K, Okada T, Hashimoto N: Histological analysis of microbleed after surgical resection in a patient with moyamoya disease. The pronounced hemosiderosis in this patient is therefore considered to be a contributory cause of the unusually rapid progress of his dementia. Dallaire-Throux C, Saikali S, Richer M, Potvin O, Duchesne S. J Neuropathol Exp Neurol. The two subgroups were matched for age, gender, intelligence quotient, extent of WMH, and type and location of ischemic stroke. Hemosiderin deposition was found to be increasingly widespread in these patients; however, the specific regions affected varied from case to case. From a pathological point of view, MBs are tiny deposits of blood degradation products (mainly hemosiderin) contained within macrophages and in close spatial relationship with structurally abnormal vessels. 2009, 8: 165-174. Programs & Resources Stains. . These results suggested that (a) MBs may actually have a negative effect on cognition, independently of other concurrent vascular lesions, and (b) there seems to be an anatomical correlation between the distribution of MBs and the cognitive domains affected, suggesting a direct damage of MBs over the tissue as the pathogenic mechanism. High Signal Intensity of the Cochlear Modiolus on Unenhanced T1-Weighted Images in Classical Infratentorial Superficial Siderosis. The cautious approach to anti-thrombotic therapy in patients with these symptomatic episodes can be extended to all patients exhibiting MBs. Nakata Y, Shiga K, Yoshikawa K, Mizuno T, Mori S, Yamada K, Nakajima K: Subclinical brain hemorrhages in Alzheimers disease: evaluation by magnetic resonance T2*-weighted images. From a pathophysiological standpoint, MBs appear to be the expression of a hemorrhage-prone state of the brain, which might carry a greater risk of ICH. Unfortunately, no proven direct treatment exists for established siderosis, and workup is focused on identifying the causative lesion, although often even this is not possible. ISSN 0029-2001 (papir) ISSN 0807-7096 (nett). 2010, 74: 1954-1960. Later studies have confirmed and expanded these findings, using different study populations with different MB patterns. Sergi Martinez-Ramirez. Organs may be, but are usually not, damaged by the iron deposits. On imaging, it is classically characterized on MRI as a rim of low signal coating the surface of the brain or spinal cord, particularly noted with the gradient echo or susceptibility-weighted sequences. Neurology. Pettersen JA, Sathiyamoorthy G, Gao FQ, Szilagyi G, Nadkarni NK, St George-Hyslop P, Rogaeva E, Black SE: Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. On the other hand, several population-based studies have also reported on MB prevalence in healthy older individuals, which can be as high as 23.5% [16]. 2009, 17: 599-609. 2013, 44: 2782-2786. Superficial siderosis is a rare progressive neurodegenerative disease caused by subarachnoid hemorrhage leading to hemosiderin deposition on the pial surfaces of the central nervous system. government site. Neurology. Cognitive impairment (and dementia) represents an increasing source of severe long-term disability and will be the focus of the review in the next sections. On returning home, the patient developed symptoms of headache, nausea, and vomiting. Treatment of SS involves identification and surgical correction of the bleeding source. haemorrhage; haemosiderin; ischaemia; microbleeds; small vessel disease; stroke. Causes of Hemosiderin Staining. ARIA with hemosiderin deposition (ARIA-H), which includes microhemorrhage and superficial . Hemosiderosis can result from, Direct bleeding into the tissues that is followed by breakdown of red blood cells and release of iron to the tissues, Destruction of red blood cells within the blood vessels, leading to release of iron into the blood followed by accumulation of iron inside the kidneys as the kidneys filter waste from the blood. Lippincott Williams & Wilkins. This phenomenon, called susceptibility effect, is the basis of T2*-gradient recalled echo (GRE) imaging, which led to the definition of the current concept of radiological MBs [2] (Figure1). You quickly wipe it off, stop the spreading. parkinsonism, Parkinson-plus syndromes, chorea, myoclonus, ataxia, dystonia, or tremor) 3,4. 2011, 42: 656-661. 10.1093/brain/awq321. 10.1002/jmri.21029. Attems J: Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms. Science. van der Vlies AE, Goos JD, Barkhof F, Scheltens P, van der Flier WM: Microbleeds do not affect rate of cognitive decline in Alzheimer disease. Privacy Prevalence of Superficial Siderosis in Patients with Cerebral Amyloid Angiopathy. Three cases of superficial siderosis of the central nervous system and review of the literature. Mesker DJ, Poels MM, Ikram MA, Vernooij MW, Hofman A, Vrooman HA, van der Lugt A, Breteler MM: Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study. Hemosiderin is a strong paramagnetic material, which allows its detection when a magnetic field is applied [ 1 ]. Article 3. A unifying hypothesis for a patient with superficial siderosis, low-pressure headache, intraspinal cyst, back pain, and prominent vascularity. Most cases of renal hemosiderosis do not cause kidney damage. Ann Neurol.